When administering KEYTRUDA in combination with LENVIMA, modify the dosage of one or both drugs as appropriate. Withhold or discontinue KEYTRUDA or withhold, dose reduce, or discontinue LENVIMA as shown in this resource.
Dosage and administration for KEYTRUDA for patients with advanced renal cell carcinoma or advanced endometrial carcinoma
Dosage and administration for LENVIMA for patients with advanced renal cell carcinomaa or advanced endometrial carcinoma
Capsules are not shown at actual size.
aWhen adminstered with KEYTRUDA.
Selected Safety Information for
KEYTRUDA® (pembrolizumab)
MSI-H = microsatellite instability-high; dMMR = mismatch repair deficient; ALT = alanine aminotransferase.
Before prescribing KEYTRUDA® (pembrolizumab), please read the accompanying Prescribing Information. The Medication Guide also is available.
Selected Safety Information for
LENVIMA® (lenvatinib)
Perform an oral examination prior to treatment with LENVIMA and periodically during LENVIMA treatment. Advise patients regarding good oral hygiene practices and to consider having preventive dentistry performed prior to treatment with LENVIMA and throughout treatment with LENVIMA.
Avoid invasive dental procedures, if possible, while on LENVIMA treatment, particularly in patients at higher risk. Withhold LENVIMA for at least 1 week prior to scheduled dental surgery or invasive dental procedures, if possible. For patients requiring invasive dental procedures, discontinuation of bisphosphonate treatment may reduce the risk of ONJ.
Withhold LENVIMA if ONJ develops and restart based on clinical judgement of adequate resolution.
CNS = central nervous system; MRI = magnetic resonance imaging; QTc = corrected QT interval; ALT = alanine aminotransferase.
Before prescribing LENVIMA® (lenvatinib), please read the accompanying Prescribing Information and Patient Information.