When administering KEYTRUDA in combination with LENVIMA, modify the dosage of one or both drugs as appropriate. Withhold or discontinue KEYTRUDA or withhold, dose reduce, or discontinue LENVIMA as shown in this resource.
Dosage and administration for KEYTRUDA for patients with advanced renal cell carcinoma or advanced endometrial carcinoma
Dosage and administration for LENVIMA for patients with advanced renal cell carcinoma or advanced endometrial carcinomaa
Capsules are not shown at actual size.
aWhen administered with KEYTRUDA.
Capsules are not shown at actual size.
If LENVIMA suspension is not used at the time of preparation, LENVIMA suspension may be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) for a maximum of 24 hours in a covered container. If not administered within 24 hours, the suspension should be discarded.
Note: Compatibility has been confirmed for polypropylene syringes and for feeding tubes of at least
5 French diameter (polyvinyl chloride or polyurethane tube) and at least 6 French diameter (silicone tube).
Selected Safety Information for
KEYTRUDA® (pembrolizumab)
MSI-H = microsatellite instability-high; pMMR = mismatch repair proficient; ALT = alanine aminotransferase.
Before prescribing KEYTRUDA® (pembrolizumab), please read the accompanying Prescribing Information. The Medication Guide also is available.
Selected Safety Information for
LENVIMA® (lenvatinib)
Perform an oral examination prior to treatment with LENVIMA and periodically during LENVIMA treatment. Advise patients regarding good oral hygiene practices and to consider having preventive dentistry performed prior to treatment with LENVIMA and throughout treatment with LENVIMA.
Avoid invasive dental procedures, if possible, while on LENVIMA treatment, particularly in patients at higher risk. Withhold LENVIMA for at least 1 week prior to scheduled dental surgery or invasive dental procedures, if possible. For patients requiring invasive dental procedures, discontinuation of bisphosphonate treatment may reduce the risk of ONJ.
Withhold LENVIMA if ONJ develops and restart based on clinical judgement of adequate resolution.
CNS = central nervous system; MRI = magnetic resonance imaging; QTc = corrected QT interval; ALT = alanine aminotransferase.
Before prescribing LENVIMA® (lenvatinib), please read the accompanying Prescribing Information and Patient Information.